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KMID : 1134820210500070672
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Journal of the Korean Society of Food Science and Nutrition
2021 Volume.50 No. 7 p.672 ~ p.678
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Inhibition of Alveolar Bone Destruction by Red Ginseng Extract in an Experimental Animal Periodontitis Model
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Jung Bo-Hyun
Ma Deuk-Sang
Yoo Ki-Yeon
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Abstract
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Periodontitis is characterized by the inflammation of the periodontal apparatus due to bacterial infection. This study sought to evaluate the effects of red ginseng extract on alveolar bone destruction in mice with ligature-induced periodontitis (LIP). The red ginseng extract stock solution was diluted in the ratios of 200 mg/kg and 400 mg/kg. The LIP animal model was administered 50 μL of each extract twice a day orally for 14 days. After 14 days, alveolar bone loss was analyzed by micro-computed tomography and tissue staining. It was observed that alveolar bone loss reduced in the experimental animal group that was administered red ginseng extract, and the gingival epithelium also showed recovery from periodontitis. These results suggest that red ginseng extract could inhibit alveolar bone destruction.
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KEYWORD
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alveolar bone, gingival epithelium, inflammation, periodontitis, red ginseng
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